The following articles are merged in Scholar. Overview; Fingerprint; Network; Research Output (8) Similar Profiles (28) If you made any changes in Pure these will be visible here soon. Technology development 7 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, the Netherlands. We use this approach to understand how gene-expression is controlled and to obtain insight into the regulatory mechanisms that govern cellular decision making in mouse early embryogenesis. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Jop Kind, group leader at the Hubrecht Institute, has been awarded the John Kendrew award. Kim L de Luca 1 , Jop Kind 2 ... 1 Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht and Oncode Institute, Utrecht, The Netherlands. Sort by citations Sort by year Sort by title. The grant enables them to develop their own innovative line of research and set up their own research group. Contact. Single cell epigenomics. Knipscheer’s group will use the ERC grant to further research this pathway. Jop Kind, Group Leader at Hubrecht Institute and Oncode Investigator, will bring you up to speed with the basics of Single Cell Technology. ERC-starting grant for Marvin Tanenbaum and Jop Kind. Follow. Read more | 18 November . 23. Oncode Investigator at Hubrecht Institute My Research Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. Erasmus University Medical Center/ UFO Biosciences, NL . jop kind. About. Articles … Molecular mechanisms and regulation of DNA repair; Hubrecht Institute. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute, A major interest in the group is how gene-expression control is achieved in early embryogenesis. These topic labels come from the works of this person. Kind’s group previously developed advanced techniques with which they can study epigenetics in a single cell and match it with the cell’s choice of identity. Online event. martin 1st April 2015 News Read more Hiding in plain sight See what employees say about what it's like to work at Hubrecht Institute. Hubrecht Institute opens new laboratory building. Salaries, reviews, and more - all posted by employees working at Hubrecht Institute. Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. Susanne Lens Group. Royal Netherlands Academy of Arts & Sciences (KNAW), Hubrecht Institute; 2015 2020. Over 17 years of experience in Molecular Biology, Yuva completed her MSc. Despite extensive research into the molecular pathways that sense and repair DNA double-strand breaks (DSBs), comparatively little is known about management of breaks within different genomic and chromatin contexts. Molecular mechanisms and regulation of DNA repair; Hubrecht Institute . ). PhD. Hubrecht Institute Summary: ... but instead attached to the ceiling at anchor points," says Jop Kind, group leader at the Hubrecht Institute. Jop Kind, Junior Group Leader at the Hubrecht Institute. Award ceremony photo gallery. “Our overarching goal is to further research current pathways and discover new ones in order to better understand how cells repair this type of DNA damage”, says Knipscheer. Biomedical genomics; Hubrecht Institute. Jop Kind leads a Developmental Epigenomics group at Hubrecht Institute, Netherlands. 3,331. Jop Kind EMBL: Predoc, Akhtar group, Genome Biology, 2002-2008. Geert Kops Group. Chromosomal regions that associate with a thin filamentous lamina layer at the nuclear periphery are generally in an inactive transcriptional state (Guerreiro and Kind, 2019, Curr.Opin.Gen.Dev.). We employ our single-cell genomic methods to study cellular trajectories on route towards malignant metastatic identities. The early mammalian conceptus (blastocyst) contains two supporting extraembryonic tissues - the trophectoderm and the primitive endoderm (PrE) - that encase and guide the epiblast (Epi) to eventually form the all body. PHOTO: EMBL . To be announced. Mechanisms underlying cell-fate choice in early embryogenesis A major interest in the group is how gene-expression control is achieved in early embryogenesis. Best Cities for Jobs 2020 NEW! Tumor-cell trajectories in organoid and mouse models Miao-Ping Chien. Because DamID-signals are stable and can be carried-over for multiple generations, we are also looking into ways to exploit this property of DamID to study DSB-repair in the context of cellular decision making. Hubrecht Institute. About. Jop Kind, Junior Group Leader at the Hubrecht Institute. In addition, we profile the epigenetic landscapes, chromatin accessibility and transcriptome in single cells. 3 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research. Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (Figure 3). Jop Kind lab. jop kind Hubrecht Institute Verified email at hubrecht.eu. Key words: Single-cell genomics, epigenetics, spatial genome organization, bioinformatics, gene-regulation, embryogenesis, tumorigenesis. Jop is currently an associate professor at the Hubrecht Institute in Utrecht where his lab continues to develop new techniques to single-cell profile gene-regulation to obtain better insights into the mechanisms that govern cell fate choice in development and disease. Jop Kind received his PhD from the Radboud University Nijmegen in 2008 for his work on chromatin and gene expression in the research group of Asifa Akhtar at EMBL Heidelberg. 3584 CT Utrecht Jop Kind, group leader at the Hubrecht Institute, has been awarded a NWO Vidi-grant. The research group of Knipscheer researches DNA repair: how does our genetic material remain stable and how do we prevent the development of genetic diseases such as cancer? To study DSB-repair in single cells, we have adapted scDam&T to generate maps of DSB-repair sites in single cells. This is particularly difficult to study because DSBs occur randomly in the genome, thus every single cell harbors a different DSB-landscape. Afterwards, Alexander van Oudenaarden, Mauro Muraro and Waleed Kholosy will also give talks and elaborate on some specific applications and usage of single cell technology. Publications 23. To be announced. We are particularly interested in understanding the role of epigenetics and spatial genome organization in this process. Visit Kind's page. A large proportion of the metazoan genome is spatially segregated at the nuclear periphery through genomic contacts with the nuclear lamina, a thin meshwork of lamin filaments that lines the inner-nuclear membrane. Save the date! Past events. Jop Kind. Chromatin cartographer EMBL alumnus Jop Kind, this year’s John Kendrew Award winner, reflects on the imaginative questions that led him to the prize . Isabel Guerreiro 1 , Jop Kind 2 Affiliations 1 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Network. … EMBL alumnus Jop Kind’s research focuses on the role of DNA organisation in genome stability, cell development and disease. 1 Institute of Epigenetics and Stem Cells (IES), Helmholtz Zentrum München, Munich, Germany. Jop Kind. Jop Kind. Jop Kind obtained his PhD from the Radboud University in Nijmegen for his work on dosage compensation in the lab of Asifa Akhtar at the EMBL Heidelberg. To this end we employ and continuously develop novel single-cell technologies to delineate these processes with high sensitivity and accuracy. To obtain detailed insight into this trajectory, it is essential to capture all the stages with single-cell accuracy. 2 day event 19 - 20 Apr. Title. By Jop Kind, Hubrecht Institute. Other Annotations. Jobs. 13:05. Kind’s work has paved the way for the development of powerful technologies to map chromatin, or balled-up DNA, in single cells, earning him this year’s John Kendrew Award. Chromosomal regions that associate with a thin filamentous lamina layer at the nuclear periphery are generally in an inactive transcriptional state (Guerreiro and Kind, 2019, Curr.Opin.Gen.Dev.). Electronic address: [email protected]. Hubrecht Institute, NL. [email protected]. Seeing is sequencing: linking phenotypes and genotypes of heterogeneous cancer cells by high-throughput, microscopy-based single cell selection and functionally annotated single cell sequencing. That knowledge underlines the link between alcohol consumption and cancer. KIT, Royal Tropical Institute. Ester Frische; Mariëlle Harlé; Yuva Oz; Jacqueline Staring; Peter Thijssen; More information will follow. Self-organization in embryology. This "Cited by" count includes citations to the following articles in Scholar. [email protected]. Accurate repair of DNA damage is critical for the maintenance of genomic integrity. The grant allows her to expand her group with 4 researchers for the duration of 5 years. Get Funding: Convey the impact of your scientific vision. Biography. Cell-fate decisions and the role of epigenetics in DNA double-strand repair Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. Friends raise €290.800,- for Hubrecht Institute. This type of DNA damage can have an endogenous cause, but it can also be caused by external influences, such as high dosages of chemotherapy in cancer. 13:35. 2016: Group Leader, Hubrecht Institute, Utrecht, The Netherlands. The researchers in Kind’s group will use the ERC grant to further research when and how cells make these identity choices. Wouter de Laat Group. Puck Knipscheer and Jop Kind, both group leader at the Hubrecht Institute and Oncode investigator, individually receive a prestigious European Research Council (ERC) Consolidator Grant. This is harmful because it prevents the DNA from replicating and thereby makes it impossible for cells to divide. Miao-Ping Chien. Oncode is an independent institute dedicated to understanding cancer and translating research into practice. Cited by. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park. 3584 CT Utrecht Jobs. About the Hubrecht Institute [email protected]. We use this approach to understand how gene-expression is controlled and to obtain insight into the regulatory mechanisms that govern cellular decision making in mouse early embryogenesis. A major interest in the group is how gene-expression control is achieved in early embryogenesis. Electronic address: [email protected]. A. Lochs †, Samy Kefalopoulou † and Jop Kind * Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, Hubrecht Institute, NL. degree at EMBL Heidelberg and conducted her PhD research on the topic of Chromatin and Biomedical Genetics at Hubrecht Institute as a Marie-Curie fellow. Sort. He made visible how 6 feet of DNA is dispersed in a cell nucleus of 10 micrometres. Nicolas Rivron. Further, in the same cells, we also profile genome-wide chromatin states with a chromatin immunocleavage (ChIC) approach to study the relationships between DSB-repair and the local chromatin environment (. The researchers want to know when and how cells in the early embryo ‘choose’ what type of cell they will become; whether they will for example become part of the skin or rather become part of the group of cells that forms the supporting embryonic tissue such as the placenta. Year; Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. Verified account Protected Tweets @; Suggested users The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Read more | 5 November . Former EMBL Genome Biology PhD student, Jop Kind, has been selected as this year’s John Kendrew Young Scientist Award winner for pioneering postdoctoral work in establishing novel technologies to map chromatin domains in single cells. Projects 1. Login as Dr. J. Royal Netherlands Academy of Arts & Sciences (KNAW) Phone +31 (0)30 212 1800; Email [email protected]; Website http://www.hubrecht.eu/ 2 Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands. 2 day event 04 - 05 Nov. Oncode - CGC Annual Conference: Basic biology meets Cancer research . Are other, currently unknown pathways involved in repairing ICLs is how gene-expression control is achieved in early embryogenesis of. 1, Jop Kind ( 1978 ) joined the Van Steensel lab as a postdoc after a highly PhD. They study how new cell types arise in the genome, thus every single cell harbors a DSB-landscape! Embryos, in which epigenetics plays an important role Yuva Oz ; Jacqueline Staring ; Thijssen... To generate maps of DSB-repair sites in single cells her MSc researchers a Vidi grant worth 800,000.... Read the new partnership Agreement between Pontiac School District and the state including exhibits of on! 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